01 - Pat the catfish fillets dry with paper towels. Season both sides with salt, pepper, and Cajun seasoning.
02 - In a shallow bowl, whisk together eggs and buttermilk until combined.
03 - In another bowl, mix cornmeal, flour, paprika, garlic powder, and onion powder.
04 - Dip each fillet first into the egg-buttermilk mixture, letting any excess drip off, then dredge generously in the cornmeal mixture. Press lightly so the coating adheres.
05 - Heat at least 2 inches of oil in a heavy skillet or deep fryer to 350°F (175°C).
06 - Fry fillets in batches, 3–4 minutes per side, until golden brown and cooked through. Do not overcrowd the pan.
07 - Drain on a wire rack or paper towels. Serve hot with lemon wedges, tartar sauce, and your favorite sides.